|
KMID : 0882420110810050602
|
|
Korean Journal of Medicine
2011 Volume.81 No. 5 p.602 ~ p.610
|
|
|
Sleep Disorder Associated with Gastroesophageal Reflux Disease
|
|
Choi Ju-Young
Jung Hye-Kyung
Roh Sun-Hee
Tae Chung-Hyun
Kim Seong-Eun
Shim Ki-Nam
Jung Sung-Ae
|
|
|
Abstract
|
|
|
Background/Aims:Gastroesophageal reflux disease (GERD) may contribute to the development of sleep disturbance, which may, in turn, provoke or worsen GERD. We evaluated the prevalence of GERD, non-erosive reflux disease (NERD), and extra-esophageal syndrome in subjects with self-reported sleep disturbance.
Methods:Subjects presenting for a health check-up were enrolled. Valid self-administered questionnaires provided information about reflux symptoms and sleep disturbances. We defined insomnia as self-reported sleep disturbance that occurred at least twice a week. GERD was defined as at least weekly symptoms of heartburn or acid regurgitation. Factors affecting sleep disturbance were revealed by a logistic regression analysis.
Results:We recruited 1,701 subjects (men 57.5%; mean age 45.0 ± 15.0 years). The prevalence of sleep disturbance was 16.3%. GERD was reported in 14.8% of the subjects with insomnia and 7.1% of controls (p < 0.001). The prevalence of NERD was 13.7% in subjects with insomnia and 6.2% in controls (p < 0.001). The prevalence of extra-esophageal symptoms was higher in the insomniacs than controls. There was a significant correlation between the number of extra-esophageal symptoms and the frequency of sleep disturbance. Multivariate analysis showed that having GERD, NERD, extra-esophageal symptoms, and high depression and anxiety scores were predictors of sleep disturbance.
Conclusions:The prevalence of GERD is higher in subjects with sleep disturbance. The number of extra-esophageal symptoms was correlated with the severity of poor sleep quality, regardless of the presence of erosive change. These findings have therapeutic implications for GERD, NERD, and extra-esophageal syndrome in patients with sleep disturbance, and future trials are warranted.
|
|
|
KEYWORD
|
|
|
Insomnia, Gastroesophageal reflux disease, Non-erosive reflux disease, Extra-esophageal syndrome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|